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The pendrive easily get affected by the viruses.To prevent this viruses harm your pendrive I have a small trick.This will not harm your pendrive but protect it.The implementation is too easy and simple that any 1 can do it, so why not try now!!
1)FORMAT your PEN DRIVE
2)CREATE NEW FOLDER AND RENAME IT AS AUTORUN.INF
3)OPEN CMD AND GO TO DRIVE IN WHICH YOUR PENDRIVE IS LOCATED
4)TYPE ATTRIB(SPACE)+R(SPACE)+S(SPACE)+H(SPACE)AUTORUN.INF
5)THIS WILL LOOK LIKE attrib +r +s +h autorun.inf
6)This will work until you format your pen drive next time.

Hope this will help your pendrive protect from viruses..